Life sciences on-line: A study in hypermedia application

The main objective was to determine the feasibility of using a computer-based interactive information recall module for the Life Sciences Project Division (LSPD) at NASA, Johnson Space Center. LSPD personnel prepare payload experiments to test and monitor physiological functions in zero gravity. Training refreshers and other types of online help are needed to support personnel in their tasks during mission testing and in flight. Results of a survey of other hypermedia and multimedia developers and lessons learned by the developer of the LSPD prototype module are presented. Related issues and future applications are also discussed and further hypermedia development within the LSPD is recommended

Lightweight device to stimulate and monitor human vestibulo-ocular reflex

A helmet formed of a rigid shell is disclosed. The shell is lined with several air filled bladders to contact firmly the head of a user. The shell has a rigid chin bar supporting a bite bar connected fixedly to a mouthpiece bearing against the teeth and hard palate to firmly anchor the helmet without movement. The outer shell surface supports various air pumping bulbs and accelerometers. Separate left and right visor pivot on the side guided in a central tongue and groove track to move optical lens mounts into the user's field of vision. The chin bar is connected to the shell by a pair of releasable clasps. A safety lanyard connects to the clasps to quickly pull pins from the clasps to enable quick release in case of motion sickness

Training scholars in dissemination and implementation research for cancer prevention and control: A mentored approach

Abstract Background As the field of D&I (dissemination and implementation) science grows to meet the need for more effective and timely applications of research findings in routine practice, the demand for formalized training programs has increased concurrently. The Mentored Training for Dissemination and Implementation Research in Cancer (MT-DIRC) Program aims to build capacity in the cancer control D&I research workforce, especially among early career researchers. This paper outlines the various components of the program and reports results of systematic evaluations to ascertain its effectiveness. Methods Essential features of the program include selection of early career fellows or more experienced investigators with a focus relevant to cancer control transitioning to a D&I research focus, a 5-day intensive training institute, ongoing peer and senior mentoring, mentored planning and work on a D&I research proposal or project, limited pilot funding, and training and ongoing improvement activities for mentors. The core faculty and staff members of the MT-DIRC program gathered baseline and ongoing evaluation data regarding D&I skill acquisition and mentoring competency through participant surveys and analyzed it by iterative collective reflection. Results A majority (79%) of fellows are female, assistant professors (55%); 59% are in allied health disciplines, and 48% focus on cancer prevention research. Forty-three D&I research competencies were assessed; all improved from baseline to 6 and 18 months. These effects were apparent across beginner, intermediate, and advanced initial D&I competency levels and across the competency domains. Mentoring competency was rated very highly by the fellows––higher than rated by the mentors themselves. The importance of different mentoring activities, as rated by the fellows, was generally congruent with their satisfaction with the activities, with the exception of relatively greater satisfaction with the degree of emotional support and relatively lower satisfaction for skill building and opportunity initially. Conclusions These first years of MT-DIRC demonstrated the program’s ability to attract, engage, and improve fellows’ competencies and skills and implement a multicomponent mentoring program that was well received. This account of the program can serve as a basis for potential replication and evolution of this model in training future D&I science researchers

Development of a Time Efficient Protocol for Cross-Limb Comparisons of Muscle Mitochondrial Capacity Using NIRS

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Large-scale Dynamo Action Driven by Velocity Shear and Rotating Convection

By incorporating a large-scale shear flow into turbulent rotating convection, we show that a sufficiently strong shear can promote dynamo action in flows that in the absence of shear do not act as dynamos. Our results are consistent with a dynamo driven by either the shear-current effect or by the interaction between a fluctuating $\alpha$-effect and the velocity shear; they are though inconsistent with either a classical $\alpha^2$ or $\alpha \omega$ mean field dynamo.Comment: 4 pages, 4 fig

Parametric Forcing of Waves with Non-Monotonic Dispersion Relation: Domain Structures in Ferrofluids?

Surface waves on ferrofluids exposed to a dc-magnetic field exhibit a non-monotonic dispersion relation. The effect of a parametric driving on such waves is studied within suitable coupled Ginzburg-Landau equations. Due to the non-monotonicity the neutral curve for the excitation of standing waves can have up to three minima. The stability of the waves with respect to long-wave perturbations is determined $via$ a phase-diffusion equation. It shows that the band of stable wave numbers can split up into two or three sub-bands. The resulting competition between the wave numbers corresponding to the respective sub-bands leads quite naturally to patterns consisting of multiple domains of standing waves which differ in their wave number. The coarsening dynamics of such domain structures is addressed.Comment: 23 pages, 6 postscript figures, composed using RevTeX. Submitted to PR

ASCA X-ray source catalogue in the Galactic Center region

The ASCA satellite made 107 pointing observations on a 5 x 5 deg^2 region around the center of our Milky Way Galaxy (the Galactic Center) from 1993 to 1999. In the X-ray images of the 0.7--3 keV or 3--10 keV bands, we found 52 point sources and a dozen diffuse sources. All the point sources are uniformly fitted with an absorbed power-law model. For selected bright sources, Sgr A*, AX J1745.6-2901, A 1742-294, SLX 1744-300, GRO J1744-28, SLX 1737-282, GRS 1734-292, AX J1749.2-2725, KS 1741-293, GRS 1741.9-2853, and an unusual flare source XTE J1739-302, we present further detailed spectral and timing analyses, and discuss their nature. The dozen extended X-ray sources comprise radio supernova remnants, giant molecular clouds, and some new discoveries. Most show emission lines from either highly ionized atoms or low-ionized irons. The X-ray spectra were fitted with either a thin thermal or power-law model. This paper summarizes the results and provides the ASCA X-ray source catalogue in the Galactic Center region.Comment: 33 pages, 8 figures, Accepted for publication in ApJS, also found in http://www.star.le.ac.uk/~mas/research/paper/#Sakano2001apj

Increased hypolipidemic benefits of cis-9, trans-11 conjugated linoleic acid in combination with trans-11 vaccenic acid in a rodent model of the metabolic syndrome, the JCR:LA-cp rat

<p>Abstract</p> <p>Background</p> <p>Conjugated linoleic acid (<it>cis</it>-9, <it>trans</it>-11 CLA) and <it>trans</it>-11 vaccenic acid (VA) are found naturally in ruminant-derived foods. CLA has been shown to have numerous potential health related effects and has been extensively investigated. More recently, we have shown that VA has lipid-lowering properties associated with reduced hepatic lipidogenesis and chylomicron secretion in the JCR:LA<it>-cp </it>rat. The aim of this study was to evaluate potential additional hypolipidemic effects of purified forms of CLA and VA in an animal model of the metabolic syndrome (the JCR:LA-<it>cp </it>rat).</p> <p>Methods</p> <p>Twenty four obese JCR:LA-<it>cp </it>rats were randomized and assigned to one of three nutritionally adequate iso-caloric diets containing 1% w/w cholesterol and 15% w/w fat for 16 wk: 1) control diet (CD), 2) 1.0% w/w <it>cis</it>-9, <it>trans</it>-11 CLA (CLA), 3) 1.0% w/w VA and 1% w/w <it>cis</it>-9, <it>trans</it>-11 CLA (VA+CLA). Lean rats were fed the CD to represent normolipidemic conditions.</p> <p>Results</p> <p>Fasting plasma triglyceride (TG), total cholesterol and LDL-cholesterol concentrations were reduced in obese rats fed either the CLA diet or the VA+CLA diet as compared to the obese control group (p < 0.05, p < 0.001; p < 0.001, p < 0.01; p < 0.01, p < 0.001, respectively). The VA+CLA diet reduced plasma TG and LDL-cholesterol to the level of the normolipidemic lean rats and further decreased nonesterified fatty acids compared to the CLA diet alone. Interestingly, rats fed the VA+CLA diet had a higher food intake but lower body weight than the CLA fed group (P < 0.05). Liver weight and TG content were lower in rats fed either CLA (p < 0.05) or VA+CLA diets (p < 0.001) compared to obese control, consistent with a decreased relative protein abundance of hepatic acetyl-CoA carboxylase in both treatment groups (P < 0.01). The activity of citrate synthase was increased in liver and adipose tissue of rats fed, CLA and VA+CLA diets (p < 0.001) compared to obese control, suggesting increased mitochondrial fatty acid oxidative capacity.</p> <p>Conclusion</p> <p>We demonstrate that the hypolipidemic effects of chronic <it>cis</it>-9, <it>trans</it>-11 CLA supplementation on circulating dyslipidemia and hepatic steatosis are enhanced by the addition of VA in the JCR:LA-<it>cp </it>rat.</p